Dimethyl Sulfoxide
Apexbio Technology LLC Foretinib (GSK1363089) 849217-64-7 10mM (in 1mL DMSO)
Foretinib (GSK1363089 CAS 849217-64-7) is a small molecule inhibitor targeting receptor tyrosine kinases involved in angiogenesis and tumor progression notably receptors for vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) Foretinib inhibits tyrosine kinase activity of Met Ron KDR Flt-1 Flt-4 KIT Flt-3 Tie-2 and PDGFR / exhibiting IC50 values ranging from 0 4 to 9 6 nmol/L In cell-based assays foretinib reduces MET phosphorylation in mouse B16F10 melanoma and human PC-3 prostate cells (IC50 21 23 nmol/L) inhibits HGF-induced cell migration invasion and suppresses proliferation in B16F10 A549 and HT29 tumor cell lines Foretinib is utilized in preclinical cancer research targeting angiogenesis invasion and metastasis pathways
Apexbio Technology LLC Phenacetin 62-44-2 10mM (in 1mL DMSO)
Phenacetin (CAS 62-44-2) is a synthetic non-opioid analgesic historically utilized for alleviating pain and reducing fever lacking intrinsic anti-inflammatory effects Its analgesic mechanism primarily involves inhibition of cyclooxygenase (COX) enzyme activity in the central nervous system leading to decreased prostaglandin synthesis Previously studied for its pharmacological action on pain modulation pathways phenacetin serves currently as an experimental reference compound in evaluating nephrotoxic effects in biomedical research following its market withdrawal due to nephropathy concerns
Apexbio Technology LLC Oseltamivir 196618-13-0 10mM (in 1mL DMSO)
Oseltamivir is a neuraminidase inhibitor targeting influenza virus replication It functions as a prodrug metabolized into oseltamivir carboxylate by host esterases This active metabolite binds to viral neuraminidase thereby blocking cleavage of terminal -Neu5Ac residues and subsequent viral progeny release from infected host cells Oseltamivir has been widely employed in investigative studies addressing antiviral efficacy resistance mechanisms and clinical outcomes in influenza infection research The compound is frequently used in vitro to characterize neuraminidase activity inhibition typically reporting IC50 values in the low nanomolar range (approximately 0 1-5 nM) depending on the influenza viral strain and assay conditions influencing viral replication and transmission
Apexbio Technology LLC Y-27632 dihydrochloride 129830-38-2 10mM (in 1mL DMSO)
Y-27632 dihydrochloride (CAS 129830-38-2) is a small-molecule inhibitor targeting ROCK kinases (Rho-associated protein kinases) specifically interacting with the catalytic domains of ROCK-1 and ROCK-2 It inhibits their kinase activity with an IC50 of approximately 140 nM By targeting ROCK signaling Y-27632 disrupts Rho-mediated formation of cellular stress fibers influences cell cycle progression from G1 to S phase and interferes with cytokinesis It is commonly utilized in studies investigating cell proliferation cytoskeletal organization and stem cell viability
Apexbio Technology LLC (S)-(+)-Ibuprofen(Synonyms: Dexibuprofen, (S)-Ibuprofen, (S)-(+)-2-(4-Isobutylphenyl)propionic acid), 10mM (in 1mL DMSO), CAS: 51146-56-6.
(S)-( )-Ibuprofen (CAS 51146-56-6) is the pharmacologically active enantiomer of the racemic nonsteroidal anti-inflammatory drug (NSAID) ibuprofen Unlike its R(-)-counterpart the S( )-form selectively inhibits cyclooxygenase (COX) enzymes thereby suppressing prostaglandin synthesis at concentrations relevant to clinical settings Due to this stereoselectivity (S)-( )-ibuprofen is widely utilized in biomedical research investigating pain inflammation pathways COX enzyme activity and related drug-target interactions
Apexbio Technology LLC Sorafenib(Synonyms: Nexavar, BAY 43-9006, BAY-43-9006, BAY439006, Sorafenib Tosylate, BAY-545-9085), 10mM (in 1mL DMSO), CAS: 284461-73-0.
Sorafenib (CAS 284461-73-0) is an orally bioavailable small molecule inhibitor targeting multiple kinases including Raf kinase as well as receptor tyrosine kinases such as VEGFR2 PDGFR FLT3 Ret and c-Kit By inhibiting Raf signaling pathways sorafenib suppresses tumor cell proliferation induces apoptosis and disrupts tumor angiogenesis In vitro studies demonstrate that sorafenib effectively inhibits Raf-mediated signaling cascades and blocks the proliferation of tumor cells Sorafenib serves as an important research tool in the study of cancer biology particularly in investigating antiangiogenic and antiproliferative mechanisms in various tumor models
Supply Solutions Dimethyl sulfoxide | 67-68-5 | 78.14 g/mol | 50ML
Dimethyl sulfoxide | 67-68-5 | 78.14 g/mol | 50ML
Apexbio Technology LLC SGX-523 1022150-57-7 10mM (in 1mL DMSO)
SGX-523 (CAS 1022150-57-7) is an ATP-competitive selective inhibitor targeting the receptor tyrosine kinase c-Met (hepatocyte growth factor receptor) It effectively blocks c-Met autophosphorylation in gastric carcinoma cell line GTL16 (IC50 40 nM) and human lung cancer cell line A549 (IC50 12 nM) In vivo studies demonstrate tumor regression upon oral administration of SGX-523 in mouse xenograft models of GTL16 and human GBM cell line U87MG Moreover it inhibits phosphorylation of MEK MAPK and Akt pathways reducing proliferation migration invasion and cell cycle progression in glioma cell models SGX-523 serves as an important research tool for oncology studies involving c-Met signaling
Apexbio Technology LLC Ivacaftor (VX-770)(Synonyms: Kalydeco, VX-770, Ivacaftor, CFTR Potentiator VX-770, Ivacaftor VX-770), 10mM (in 1mL DMSO), CAS: 873054-44-5.
Ivacaftor (VX-770 CAS 873054-44-5) is an orally bioavailable small molecule potentiator targeting the cystic fibrosis transmembrane conductance regulator (CFTR) Ivacaftor enhances CFTR-mediated chloride ion transport especially in cells expressing G551D- or F508del-CFTR mutations In vitro studies demonstrated that Ivacaftor in combination with forskolin significantly increased CFTR-dependent chloride secretion (EC50 100 nM in G551D- 25 nM in F508del-expressing cells) Similarly Ivacaftor reduced ENaC-mediated sodium reabsorption and increased airway surface liquid volume in human cystic fibrosis bronchial epithelial cells Ivacaftor is utilized in research to investigate CFTR function restoration and associated ion transport processes
Apexbio Technology LLC JIB-04 199596-05-9 10mM (in 1mL DMSO)
JIB-04 (CAS 199596-05-9) is a selective small-molecule inhibitor targeting Jumonji histone demethylases specifically suppressing enzymes including JARID1A JMJD2 family members (JMJD2A-E) and JMJD3 Structurally categorized as a pyridine hydrazone derivative JIB-04 inhibits demethylase activity independently of competitive binding with -ketoglutarate In vitro assays revealed IC50 values ranging from 230 nM to 1100 nM across various Jumonji enzymes Additionally JIB-04 demonstrates preferential inhibition of cancer cell proliferation versus normal cells notably in lung and prostate cancer cell lines and effectively reduces tumor growth in mouse xenograft models highlighting its relevance for cancer research
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide ACS reagent, >=99.9% | 67-68-5 | MFCD00002089 | 6X1L
Dimethyl sulfoxide ACS reagent, >=99.9% | Purity: >=99.9% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 6X1L
Apexbio Technology LLC MI-77301 (SAR405838) 1303607-60-4 10mM (in 1mL DMSO)
MI-77301 (SAR405838 CAS 1303607-60-4) is a selective antagonist targeting the murine double minute 2 (MDM2) protein an E3 ubiquitin ligase responsible for negatively regulating tumor-suppressor p53 via ubiquitination and degradation By inhibiting the MDM2-p53 interaction (Ki 0 88 nM) MI-77301 stabilizes p53 elevates protein levels of p53 p21 and MDM2 and induces apoptosis Preclinical studies demonstrate selective growth inhibition in tumor cell lines harboring wild-type p53 (e g SJSA-1 RS4 11 LNCaP HCT-116) and potent tumor regressions in corresponding xenograft mouse models highlighting its utility for mechanistic studies and cancer therapeutic research