Dimethyl Sulfoxide
Apexbio Technology LLC Triptolide 38748-32-2 10mM (in 1mL DMSO)
Triptolide (CAS 38748-32-2) is a biologically active diterpenoid originally isolated from the traditional Chinese herb Tripterygium wilfordii It exerts inhibitory effects by suppressing interleukin-2 expression in activated T cells and impeding NF- B-mediated transcriptional activation Triptolide inhibits invasion and migration of ovarian cancer cells via reducing matrix metalloproteinases MMP-7 and MMP-19 expression and enhancing E-cadherin expression Additionally it induces RNA polymerase II degradation leading to apoptosis and reduced proliferation in cancer cell lines and rheumatoid arthritis synovial fibroblasts Consequently triptolide serves as a valuable tool for immunology oncology and inflammation research
Sigma Aldrich Fine Chemicals Biosciences Promethazine sulfoxide Bri
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.for further information and support please go to the website of the issuing Pharmacopoeia.
Apexbio Technology LLC Ramelteon(Synonyms: Rozerem, TAK-375, Ramelteon, Melatonin receptor agonist, MT1/MT2 agonist), 10mM (in 1mL DMSO), CAS: 196597-26-9.
Ramelteon (CAS 196597-26-9) is a potent orally active agonist selective for MT1 and MT2 melatonin receptors Structurally characterized by its S-enantiomer and ether functional group ramelteon exhibits high binding affinity toward MT1 and MT2 receptors with reported Ki values of 14 pM and 112 pM respectively whereas affinity for the MT3 receptor is considerably lower (Ki 2650 nM) By activating MT1 and MT2 receptors ramelteon suppresses cAMP production in human cells expressing these receptors with IC50 values of 21 2 pM/L (MT1) and 53 4 pM/L (MT2) Given its receptor selectivity and minimal side-effect profile ramelteon is frequently utilized in research investigating circadian rhythms and sleep disorders
![Apexbio Technology LLC Scriptaid(Synonyms: Scriptaid, HDAC inhibitor Scriptaid, 6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide), 10mM (in 1mL DMSO), CAS: 287383-59-9.](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000060690.PNG-250.jpg)
Apexbio Technology LLC Scriptaid(Synonyms: Scriptaid, HDAC inhibitor Scriptaid, 6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide), 10mM (in 1mL DMSO), CAS: 287383-59-9.
Scriptaid (CAS 287383-59-9) is a small-molecule histone deacetylase (HDAC) inhibitor originally identified through high-throughput transcriptional screening It specifically targets class I HDAC isoforms inhibiting HDAC1/HDAC3 and HDAC8 with IC50 values of approximately 0 6 M and 1 M respectively Structurally related to other hydroxamic acid-containing HDAC inhibitors such as TSA Scriptaid consists of a hydroxamic acid moiety a connecting linker and an aromatic cap group In glioblastoma (GBM) research Scriptaid shows promise by inducing apoptosis in glioma cells highlighting its potential utility for oncology-focused investigations
Apexbio Technology LLC Flumethasone 2135-17-3 10mM (in 1mL DMSO)
Flumethasone is a glucocorticoid receptor agonist functioning by binding to intracellular glucocorticoid receptors (GR) and forming a receptor-ligand complex Upon formation this complex translocates into the nucleus modulating transcriptional activity through interactions with glucocorticoid response elements (GREs) subsequently altering gene expression patterns that regulate inflammation immune responses and cellular metabolism Flumethasone is commonly used in biomedical research involving inflammatory and autoimmune disease models to investigate glucocorticoid-mediated regulatory mechanisms receptor signaling pathways and gene expression modulation Reported GR-binding assays indicate Flumethasone exhibits an IC50 value in the low nanomolar range reflecting its potent receptor affinity allowing quantitative analyses and mechanistic studies on glucocorticoid-mediated biological effects
Apexbio Technology LLC PD 151746 179461-52-0 10mM (in 1mL DMSO)
PD 151746 is a cell-permeable inhibitor that selectively targets calpain a calcium-dependent cysteine protease involved in various cellular processes With a Ki value of 0 26 M against -calpain it prevents the proteolytic cleavage of substrates like neuronal nitric oxide synthase (nNOS) and calmodulin-dependent protein kinase II-alpha (CaMPK-II) particularly under stress In neuronal models PD 151746 inhibits apoptosis induced by serum/potassium withdrawal reduces MEF2 phosphorylation suppresses cdk5/p25 complex formation and decreases caspase-3 activation In HepG2 hepatoma cells it disrupts insulin-stimulated glycogen synthesis and affects protein tyrosine phosphatase-2 (PTP2) expression PD 151746 is used in research to study calpain-related signaling pathways apoptosis cell motility and metabolism
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 100.0% | 78.13 g/mol | C2H6OS | 50mL
Dimethyl sulfoxide (DMSO) (GMP Like) is the GMP Like class Dimethyl sulfoxide (HY-Y0320C) Dimethyl sulfoxide is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents Dimethyl sulfoxide has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity[1]
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide Reagent1L
Dimethyl sulfoxide is an amphipathic molecule soluble in both aqueous and organic solvents. It is commonly used as an aprotic solvent and also as a reagent in organic synthesis.
Apexbio Technology LLC BI6727 (Volasertib)(Synonyms: Volasertib, BI-6727, BI 6727, Plk inhibitor BI6727, Polo-like kinase inhibitor BI6727), 10mM (in 1mL DMSO), CAS: 755038-65-4.
BI6727 (Volasertib CAS 755038-65-4) is a selective inhibitor of Polo-like kinases (Plk) primarily targeting Plk1 with an IC50 of 0 87 nM and showing lower potency towards Plk2 (IC50 5 nM) and Plk3 (IC50 56 nM) Plk1 regulates the G2/M cell cycle transition and is commonly overexpressed in various tumor types representing a potential therapeutic target BI6727 inhibits proliferation across multiple tumor cell lines including colorectal (HCT116 EC50 23 nM) lung (NCI-H460 EC50 21 nM) melanoma (BRO EC50 11 nM) and hematologic cancer (GRANTA EC50 15 nM) In vivo BI6727 administration induced apoptosis and reduced tumor growth in mouse HCT116 and NCI-H460 xenograft models
Apexbio Technology LLC Pioglitazone(Synonyms: Actos, Pioglitazone Hydrochloride, AD-4833, U-72107, Glustin, Zactos, Piozone), 10mM (in 1mL DMSO), CAS: 111025-46-8.
Pioglitazone (CAS 111025-46-8) is a small-molecule agonist selectively targeting peroxisome proliferator-activated receptor gamma (PPAR ) By activating this nuclear receptor pioglitazone influences gene expression pathways involved primarily in glucose and lipid metabolism insulin sensitivity and adipocyte differentiation It is widely employed in biomedical research focusing on metabolic disorders including type 2 diabetes mellitus insulin resistance mechanisms and associated inflammatory processes
Apexbio Technology LLC (+)-Bicuculline 485-49-4 10mM (in 1mL DMSO)
( )-Bicuculline is a competitive antagonist of gamma-aminobutyric acid type A (GABA A) receptors frequently employed as a pharmacological tool to elucidate the functional roles of inhibitory neurotransmission mediated by GABA A By antagonizing GABA binding this compound prevents chloride ion influx leading to reductions in neuronal inhibitory postsynaptic potentials (IPSPs) Additionally ( )-Bicuculline blocks small conductance calcium-activated potassium (SK) channels affecting neuronal excitability and firing patterns It is commonly utilized in electrophysiological studies such as patch-clamp or extracellular recordings to investigate synaptic transmission neuroplasticity mechanisms and epileptic activity models ( )-Bicuculline inhibits GABA A receptors with an IC 50 typically reported in the low micromolar range (approximately 2 5 M)
Medchemexpress LLC Deg-77 10Mm 1Ml /Dmso Solution | HY-157334-10MM 1ML SOLUTN
Deg-77 10Mm 1Ml /Dmso Solution
Apexbio Technology LLC VX-661(Synonyms: Tezacaftor, VX661, VX-661, VX 661), 10mM (in 1mL DMSO), CAS: 1152311-62-0.
VX-661 (CAS 1152311-62-0) is a small-molecule CFTR corrector developed by Vertex Pharmaceuticals designed to restore trafficking and enhance cellular surface expression of the mutated F508del-CFTR protein By facilitating proper folding and transport of this commonly mutated cystic fibrosis transmembrane conductance regulator (CFTR) VX-661 increases CFTR-mediated chloride channel activity in vitro Preclinical and clinical research have explored VX-661 alone and in combination with ivacaftor demonstrating enhanced F508del-CFTR functionality and providing a promising strategy for addressing cystic fibrosis caused by the F508del mutation
Apexbio Technology LLC PTC124 (Ataluren) 775304-57-9 10mM (in 1mL DMSO)
PTC124 (Ataluren CAS 775304-57-9) is a small molecule modulator that selectively targets premature termination codons (nonsense mutations) which are point mutations causing early termination during translation By promoting ribosomal read-through of these mutations PTC124 enhances the synthesis of full-length functional proteins In vitro studies demonstrated its activity at IC50 of approximately 0 1 M Research in MDX mouse skeletal muscle cells and human induced pluripotent stem cell-derived retinal pigment epithelium cells confirmed its capacity to restore protein production Animal models of Duchenne muscular dystrophy and cystic fibrosis exhibited improved muscle and channel protein function upon oral or subcutaneous administration suggesting its potential for addressing genetic diseases associated with nonsense mutations